A simple method to find out erythrocyte density

Korpinar MA, Akcasu A, Kalkan MT, Korpinar U

Cerrahpasa J Med 1995;26: 77-79.

BACKGROUND AND DESIGN: The aim of this study is to describe a new simple method to measure erythrocyte density, an important parameter of erythrocyte sedimentation rate. According to this approach, % NaCl solutions of 11 different concentrations are prepared. Erytrocytes purified of plasma are dripped into these solutions with the help of glass pipettes arranged in L-shape. If the density of the erythrocytes is equal to that of the solution they remain in the middle if less they more upward or vica versa. RESULTS: the concentration of the solution which is equal to the density of the erythrocyte is detsrmined, and this is shown on a calibration graph which is prepared according to the known linear relation between % NaCl concentration and density. CONCLUSION: This new method design to measure erythrocyte density may enable more simple approach for clinical application. (Return)

Abdominal surgical repair of vaginal vault prolapse: Proposal of a modified technique

Uludag S, Isiloglu H, Benian A

Cerrahpasa J Med 1995;26: 80-84.

BACKGROUND AND DESIGN: Five patients with vaginal vault prolapsus following hysterectomy have been presented and a modified surgical technique for abdominal approach has been described. RESULT AND CONCLUSION: All of the patients responded to this treatment, their sexual functions were reserved and no complication was observed. (Return)

Adult non-Hodgkin's lymphomas: An immunohistochemistry based prospective survey on 333 cases

Tuzuner N, Dogusoy G, Uraz S, Oz F

Cerrahpasa J Med 1995;26: 85-89.

BACKGROUND: The histologic subtypes of 333 consecutive adult non-Hodgkin's lymphoma between 1990-1992 were classified according to Working Formulation (WF). DESIGN: Immunophenotype was determined with L-26 and UCHL-1 monoclonal antibodies by using APAAP technique on paraffin sections. RESULTS: Phenotypic studies characterized these lymphomas as B cell (78%) and T cell (22%) type. Marked morphologic and immunologic heterogeneity was noted within the mixed cell and large cell categories. CONCLUSION: Morphologic classification of T cell lymphoblastic type. Although morphological features, by which peripheral T cell lymphomas may be recognized in histologic sections have been described, none of these features was found to be entirely specific for peripheral T cell lymphoma since they were also recognized in significant number of B cell lymphomas (42%). (Return)

Tracheal tumors

Cagatay T, Pisiriciler R, Yanardag H, Celikoglu F, Gulbaran Z, Papilla C, Demirci S, Karayel T, Girisken G, Celikoglu S

Cerrahpasa J Med 1995;26: 90-93.

BACKGROUND AND DESIGN: Primary tracheal tumors are very rare and show a variety of histological and clinical properties. Twety-one patients with tracheal carcinoma seen between 1985 and 1994 in Bronchopneumology Unit of Cerrahpasa Medical Faculty are presented. RESULTS: Female:male ratio was 4:17. The mean age of the patients was 53.7±17.4 with a range of 26 to 85 years. Fourteen of the patients were smokers. Nineteen of the 21 patients had a histological diagnosis, the squamous cell carcinoma being the most common (12/19). Piecemeal resection and intratumoral chemotherapy were instituted to all off the patients. This regimen was followed by systemic chemotherapy in 4, radiotherapy in 4 and laser therapy in 9 patients. Five of 9 patients who have been treated with laser showed significant recanalization of the tracheal lumen. CONCLUSION: Laser therapy combined with intratumoral chemotherapy has a beneficial effect on the survival of patients with tracheal tumors. (Return)

Cholesterol dichloride: I. Hypolipidemic effect

Akcasu A, Kaleagasioglu F, Baykut F

Cerrahpasa J Med 1995;26: 94-97.

BACKGROUND AND DESIGN: In this study, hypolipidemic activity of a novel cholesterol derivative, cholesterol dichloride (CDC), was investigated. Increasing doses (12.5, 25 and 40 mg/kg) of CDC were administered intramuscularly to New Zealand type rabbits (1.5-3.5 kg) daily except weekends. RESULTS: CDC showed a dose-dependent effect. No significant changes were observed at 12.5 mg/kg. At 25 and 40 mg/kg, serum cholesterol levels declined approximately by 50% in the third week (p<0.001). Despite the undulations in the total cholesterol levels, a more steady decrease was observed in triglyceride levels. In the sixth week, serum triglyceride levels decreased to 62% of the value determined in the second week in three of the animals (p<0.05). In all the animals which were given 40 mg/kg CDC, serum triglyceride levels fell to approximately 40.3% (26-55%) of the initial values (p<0.001). Serum low-density lipoprotein levels also fell significantly in this group (p<0.001). CONCLUSION: According to these findings, CDC has a very potent hypolipidemic effect, the mechanism of which remains to be clarified. (Return)

Macroglossia creating open bite deformity

Guzel MZ, Senyuva C, Aydin Y, Aygit AC, Yazar S

Cerrahpasa J Med 1995;26: 98-100.

BACKGROUND: Macroglossia, though relatively uncommon, is important because of its functional as well as psychological ramifications. Tongue enlargement can be either a congenital or acquired condition. In this study, a case of lymphatic malformation of the tongue with gross mandibular and maxillar deformity is presented. OBSERVATION: In this patient, large excision for macroglossia was effective for symptomatic improvement and speech intelligibility but open bite deformity remained to be a problem. (Return)

Primary bone lymphoma

Ferhanoglu B, Eralp Y, Hiz M, Tuzuner N, Akman N

Cerrahpasa J Med 1995;26: 101-104.

BACKGROUND: Primary lymphoma of bone,a rarely encountered malign lymphoid osseous tumor, accounts for up to 5% of all cases of adult extranodal non-Hodgkin lymphomas. Staging seems to be the most important prognostic determinant and correlates significantly with survival. The paucity of the selected number of patients precludes an accurate assessment of the efficacy of treatment. In tumors confined to one anatomical site, radiotherapy appears to yield promising results. However, in patients with extraskeletal involvement, combination regimens with chemotherapy and radiotherapy result in a more favorable outcome. OBSERVATION: In this study, three patients with malignant lymphoma of bone who were seen at the Cerrahpasa Medical Faculty Hematology clinic from 1990 through 1994 were placed into four groups based on stage of disease and diagnostic, therapeutical and prognostic features with clinical correlates are reviewed. (Return)


Hamuryudan V, Hizli N, Yurdakul S, Yazici H

Cerrahpasa J Med 1995;26: 105-112.

BACKGROUND: Vasculitic syndromes are charecterized by inflammation and destruction of blood vessels leading to vascular occlusion with ischemic changes in tissues. The increased awareness and diagnosis of early cases with the aid of new tools like antineutrophil cytoplasmic antibodies lead to an increase in their frequency. With the implication of Hepatitis B virus in the pathogenesis, approximately one third of the necrotizing vasculitides are not any more regarded as idiopathic. New developments have also challenged our ideas about their treatment. Therapeutic strategies aimed at the eradication of the pathogenetic agents are being introduced with remarkable success. (Return)